The Effect of Dietary Intervention with Pomegranate and Aloe Vera in Alleviating the Symptoms of Alcohol-Induced Stomach Ulcers in Experimental Rats

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

Peptic
ulcer disease is defined by open lesions in the stomach and duodenum, frequently associated with oxidative stress and inflammation. This study evaluated the therapeutic potential of a probiotic functional formula enriched with pomegranate peel extract and aloe vera gel. Thirty-five adult male rats were allocated into a negative control group (n=7 rat) and ulcer-induced groups (n=28 rat), which received a single oral dose of ethyl alcohol at a concentration of 10 ml/kg. The ulcer-induced groups were further categorized into four equal subgroups, each receiving distinct treatments: 200 mg/kg of aloe vera (AVG), 50 mg/kg of pomegranate (PMG), and a combined treatment of aloe vera and pomegranate (APG). The results indicated that the dietary interventions significantly improved hematological and antioxidant parameters. Notably, the APG group demonstrated the highest hemoglobin level (12.25±0.70 g/dl) and red blood cell (RBC) count (7.03±0.59), representing a substantial enhancement compared to the ulcer-induced control group. Additionally, antioxidant activity was markedly enhanced, with the APG group exhibiting the highest superoxide dismutase (SOD) level (25.03±0.55 u/ml) and lower malondialdehyde (MDA) levels (1.54±0.53 nmol/ml). Furthermore, the ulcer inhibition index was highest in the APG group (359.71±44.14), which also recorded the greatest protection rate (60.17±5.24%) and the lowest ulceration percentage (35.87±5.89%). These findings underscore the synergistic protective effects of aloe vera and pomegranate in mitigating gastric damage, enhancing antioxidant defenses, and promoting ulcer healing. The combined treatment exhibited significant therapeutic benefits, suggesting its potential as a natural approach for alleviating peptic ulcers and improving overall gastrointestinal health.

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