Potential Effect of Lupine Seeds (Sweet and Bitter) in Alloxan-Induced Diabetic Rats

Document Type : Original research articles

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Dept. Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

Lupinus
, a genus of plants belonging to the legume family Fabaceae, is widely recognized as Lupines. Both sweet and bitter lupine seeds are considered promising candidates for diabetic treatment. This study aimed to evaluate the effect of sweet and bitter lupine seeds on diabetic rats induced with alloxan. A total of 48 male albino rats were divided into eight groups. After a 7-day acclimatization period on a basal diet, rats in the second group were given an injection of 150mg/kg alloxan injection to induce diabetes. Group 1 was the negative control, while groups 3 and 4 were fed sweet lupine powder (2.5% to 5% of their diet weight), and groups 5 and 6 received bitter lupine powder in the same proportion. Groups 7 and 8 were given a mixture of sweet and bitter lupine powder. The results indicated that the rats receiving lupine powders significantly improved in various biochemical parameters compared to the positive control group. These impacted blood glucose, liver enzymes, lipid profiles, and kidney function (P≤0.05). Also, the treated groups had significantly elevated insulin secretion, and HDL-c levels were significantly higher in the treated groups. In conclusion, these findings suggest that sweet and bitter lupine seeds may positively influence the biochemical condition of diabetic rats, indicating their potential as a natural adjunct in diabetes management.

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