Antidiabetic Effects of Shrimp Shell-Derived Glucosamine on Biochemical, Immunological, and Hormonal Parameters in Diabetic Rats

Document Type : Original research articles

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1 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

2 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Egypt

Abstract

This study was evaluated the effect two levels of glucosamine and its source as shrimp scales extract on some organ’s functions of diabetic rats. The forty-two healthy adult male albino rats were divided into six groups, each consisting of seven rodents: As a negative control, Group (1) was administered a basal diet. Alloxan (150 mg/kg body weight) was administered subcutaneously to other groups in order to induce diabetes. One of them kept as a positive control group (Group 2) while , groups (3&4) intake standard diet with glucosamine at the dose 1.5 or 3 mg and groups (5 & 6) fed on natural diet and shrimp scales extract at the levels of 10 and 20% respectively for 28 days. The serum liver enzymes, serum kidney functions, blood glucose, and immunoglobin productions were assessed. Blood glucose, liver enzymes, kidney functions, insulin hormone, and immunoglobulin production enhancements were observed. The high level of glucose amine and its source caused the highest effect. Consequently, the research imagery indicates that the glucosamine sources in question have the potential to improve the protection against diabetes.

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