Document Type : Original research articles
Authors
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
Abstract
The current study aims to introduce the impact of bay leaves aqueous and ethanolic extracts at two concentrations (100 and 200mg/kg B.W.) on glucose levels in diabetic rats. Thirty male albino rats, Spring Dawley strain, 2-week age, weighing 150±10 g, were once divided into six groups (five rats in each group). The first group was once kept as a control (-ve) group, whilst the other five groups had been injected with alloxan (150 mg/kg/b.w) to result in diabetic rats; the second group, diabetic rats, served as positive diabetics fed on basal diet only. The third and fourth groups were treated with 100 and 200 mg/kg B.W. of bay leaves aqueous extract, whilst the fifth and sixth groups were treated with 100 and 200 mg/kg B.W. of bay leaves ethanolic extract. After 28 days, the following exams had been evaluated, fasting blood glucose, alanine aminotransferase, lipid profile (triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), and low-density lipoprotein-cholesterol (LDL-c)), oxidative enzymes like Superoxide dismutase (SOD), catalase enzyme (CAT), and malondialdehyde (MDA), kidney (creatinine, uric acid, and urea), and liver enzymes like alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), had been evaluated through biochemical tests. The results revealed that bay leaf extract reduced glucose levels, improved functions of the kidney and liver biomarkers, and enhanced lipid profile and oxidative enzymes in contrast to the positive control group. In conclusion, it is advised to use bay leaves extract for patients with diabetes, as it can potentially enhance blood sugar control.
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