Studying the Influence of Reishi Mushroom (Ganoderma lucidum) Extract on Diabetic Rats

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

This study aims to evaluate the effects of various reishi mushroom (Ganoderma lucidum) extract dosages on the blood glucose levels of diabetic rats., and influence the blood glucose levels of rats with diabetes. Five groups of 30 albino rats weighing 150±10 g have been created. One group used to be maintained as a control (-ve), and the other four groups were given intraperitoneal injections of alloxan (150 mg/kg physique weight) to Induce diabetes. One group used to be maintained as a control (+ve). Three diabetic groups of  Reishi mushroom extract at doses of 100, 200, and 300 mg/kg were administered for 28 days to treat three diabetic groups. Biochemical analysis includes blood glucose level, lipid fraction such as total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein cholesterol (VLDL-c), renal functions such as uric acid, urea, and creatinine, oxidative enzymes such as superoxide dismutase (SOD) and catalase (CAT), and malondialdehyde (MDA). Calculations have been made for body weight gain (BWG), feed intake (FI), and feed efficiency ratio (FER). The findings demonstrated that the reishi mushroom extract improved the lipid profile, kidney, and liver indicators whilst reducing the degree of blood glucose in diabetic rats. Reishi mushroom extract decreased MDA whilst elevating CAT, SOD, BWG, FI, and FER levels. In conclusion, reishi mushroom is an excellent nutraceutical therapy for diabetes in rats, as confirmed through all biochemical analyses

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