Evaluation the Influence of Bitter Wood (Quassia amara) and Nettle (Urtica dioica, L.) Roots on Biological Alterations in Diabetic Rats

Document Type : Original research articles

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1 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.

2 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

The present research sought to determine how nettle, bitter wood roots, and their powdered combinations affected rats with diabetes, induced by using alloxan. A total of forty-eight white randoms ranging around 140 and 150 g had been split into two groups of six each, every at random. Group (I): Served as the randomized group of control, and Group (II): One intra-cage injection of the diabetes-inducing drug alloxan (150 mg/kg b.wt.) was given. The rats with diabetes in Group II had been then split into seven subgroups at random: Group2, the group serving as the positive control, that just given the regular diet; group3-8, which received the standard diet plus 4% bitter wood roots, nettle roots powder, or both, for a duration of 4 weeks. Samples were examined for biochemical markers like glucose ranges, liver enzymes, renal function, and lipid fractions; 28 days after the experiment ended.  The results of the collected data confirmed that, in evaluation to the control positive group, the examined plants (P≤0.05) dropped serum sugar, LDL-c, and raised HDL-c. Additionally, the studied plants enhanced kidney and liver functions. According to the findings, nettle and bitter wood powder consist of a variety of active phytochemical compounds that might also minimize the adverse effects and suppress diabetic rats.

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