Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.
2
Dept. Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
3
Nutrition and food Science department, Faculty of Home Economics, Menoufia University
Abstract
The purpose of this study was once to investigate the influence of ashwagandha root powder and its ethanolic extract on infertility rats. Thirty-six male albino rats have been divided into two main groups. Group 1 used to be controlled (-) given the basal diet. Following an injection of cadmium chloride to induce infertility in the rats, the 2nd group divided into 5 groups of 6 rats each. Group (2) given a basal diet only as a control (+); groups (3–4) given a basal diet containing (2.5 and 5%) of ashwagandha root powdered; groups (5–6) given a basal diet plus (250 and 500 mg/kg) ashwagandha root ethanolic extract orally. After the four-week trial was over, the rats slaughtered, and blood was extracted to get serum. The parameters as follows have been evaluated: Serum glucose; renal biomarkers like urea, creatinine, and uric acid; hormones regarded as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone; immunological markers like IgG and IgM ranges; lipid fractions such as TC, TG, LDL-c, VLDL-c, and HDL-c; and liver enzymes like ALP, ALT, and AST. The information obtained revealed that use of ashwagandha root resulted in a significant rise in testosterone and FSH, a reduction in LH hormone, a drop in glucose, lipid fractions, renal, and liver biomarkers, and a reverse impact on HDL-c. In conclusion, ashwagandha roots are beneficial to improving the immune system and reproductive hormones in rats.
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