Effect of Sidr (Ziziphus spina christi) Extracts on Induced-Diabetic Rats

Document Type : Original research articles

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Dept. Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

This study aims to determine how Sidr (Ziziphus spina christi) seeds and leaves ethanolic extract affect glucose levels in diabetic rats. Thirty adult male albino rats weighing 150 ±10 g were divided into six groups (five rats in each group). The first group was kept as a control (-ve) group, while the other 5 groups were injected with alloxan (150 mg/kg body weight) to become diabetic rats; one group was retained as a control (+ve), while four diabetic groups were treated with two concentrations of Sidr leaves and seeds ethanolic extract (200 and 400 mg/kg). After 28 days, serum glucose level and lipids profile, including total cholesterol (T.C.), triglycerides (T.G.), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and very low-density lipoprotein cholesterol (VLDL-c), as well as kidney and liver functions indicators were measured. Oxidative enzyme levels, including malondialdehyde (MDA), superoxide dismutase (SOD), and catalase enzyme (CAT), were also assessed. Body weight gain (BWG), feed intake (F.I.), and Feed efficiency ratio (FER) were calculated. According to the findings, both Sidr leaves and seeds ethanolic extract reduced blood sugar levels and enhanced kidney and liver functions. Additionally, both leaves and seeds improved the lipid profile and oxidative enzymes compared to the positive control group. Also, enhanced F.I., FER, and BWG. A histological examination supported the biochemical experiments. In conclusion, all biochemical analysis reflects the power of Sidr leaves and seeds as nutraceutical therapy for the remedy for diabetic rats.

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