Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences,Faculty of Home Economic, Menoufia University, Shibin El-kom, Egypt
2
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
Abstract
This research aims to estimate the chemical composition and phenolic compounds of Muskmelon (Cucumis melo L.) powder and evaluate its hypoglycemic effects. Thirty male adult Sprague-Dawley rats were divided into five groups: Group (1): Negative control group (-) fed on the basic diet only, Group (2): Hyperglycemic rats - positive control group (+) fed on the basic diet only, while the groups (3, 4, 5) were hyperglycemic rats and fed the basic diet with different levels of Muskmelon powder (2.5%, 5%, 7.5%), correspondingly. After 28 days, by the end of the experiments, blood samples were collected for determination of glucose, TG, HDL-c, LDL-c, VLDL-c, ALT, AST, ALP, urea, uric acid, and creatinine. The weights of rats and the internal organs were also calculated, along with histological analyses of the liver and kidneys. The results in the hyperglycemia untreated group showed a decrease in weight gain, internal organs, and HDL, while an increase in the serum of blood glucose, TG, LDL, VLDL, ALT, AST, ALP, urea, uric acid, and creatinine. The results gradually improved using Cucumis melo L. powder (2.5%, 5%, and 7.5%), respectively; the best group was (7.5%). The histopathological examination of the liver and kidneys also showed despicable pathological histological changes in the group (2) "positive control group (+)." At the same time, significant and noticeable improvement appeared in the tissue of groups (3, 4, 5) hyperglycemic rats treated with Cucumis melo L powder (2.5%, 5%, 7.5), respectively, and the best group was (7.5%).
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