The Protective Effect of Gum Arabic on the Electrolyte Balance and Parathyroid Hormone among Osteoporotic Rats

Document Type : Original research articles

Authors

1 Department of Nutrition and Food Science,Faculty of Home Economics,Menoufia University, Shebin El-Kom, Egypt.

2 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

The present study investigated how gum Arabic affected osteoporotic rats. Thirty-five male albino rats averaging (150±170g) were used. Two major groups were; the first major group (n=5) was kept as a negative control group, while the second major group (n=30) was given oral injection of prednisolone (5 mg) to cause osteoporosis for two weeks every day, then divided into six subgroups, positive control group, treated group that take the dose of medical therapy (bonapex) only, and other four subgroups were given basal diet plus 10% or 15% of gum Arabic, and 10% or 15% of gum Arabic plus medical dose for 28 days. The results indicated that dietary intervention with gum Arabic could improve urea and creatinine concentration, which decreased gradually by increasing the dose of gum Arabic. Gum Arabic (15%) plus bonapex had the best serum electrolytes phosphorus, calcium, and magnesium values after dietary intervention among osteoporotic groups but differed significantly when compared with the control negative group. The effect of gum Arabic at a higher dose on vitamin D and Parathyroid hormone (PTH)  in gum Arabic was 15%, and it did not differ significantly from the medicine in the treated group with bonapex. In conclusion, gum Arabic had a protective effect on osteoporotic rats.

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