Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences, Faculty of Home Economics , Menoufia University,Shibin El Kom, Egypt
2
Department of Nutritiion and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
3
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
Abstract
Rheumatoid arthritis (RA) affects 0.5–1% of people; it lowers a patient's quality of life. RA is an immune-mediated condition that can cause lymphocyte and fibroblast activation, which can result in joint damage. This study aimed to evaluate the impact of custard apple juice (CAJ) on reducing RA in rats. Thirty male rats were divided into two main groups and fed a standard diet. The first group, the -ve C group (n:6), and the second group (n:24) were treated with 0.1 ml of total adjuvant injected into the right tarsal joint of each animal, and this was repeated seven days later. Signs of RA appeared after 14 days. After dividing them into four equal subgroups (6 rats each), the first +ve C group and the second, third, and fourth groups were given a daily oral dose of CAJ 5,10 and 15 μL/g (B.W), respectively. At the end of the trial (28 days), the results indicated that supplementations of CAJ led to a decrease in the level of erythrocyte sedimentation rate, anti-citrullinated protein/peptide antibody, C-reactive protein, rheumatoid factor, malondialdehyde, and Immunoglobulin G& M compared to +ve C. In contrast, total oxidant status, catalase, and glutathione peroxidase levels were increased significantly compared to the +ve C., whereas administering rats with 15 μL/g of CAJ achieved the best effects through improving the previous changes to near the normal levels. Conclusion: The custard apples enhance immunity, leukocyte count, and total antioxidant status while inhibiting the formation of inflammatory cells in RA.
Therefore, the custard apples enhance immunity, leukocyte count, and total antioxidant status while inhibiting the formation of inflammatory cells in rheumatoid arthritis.
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