Biochemical and Nutraceutical Effect of Ashwagandha (Withania Somnifera) Roots on Kidney Functions and Immunomodulatory Activity Disorders in Rats

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

Numerous plants and their extracts have been shown to significantly affect inflammation and fibrosis and improve renal dysfunction through antioxidant action. This work examined the effect of ashwagandha (Withania somnifera) roots powder (ARP), aqueous (ARAEx), and ethanolic extract (AREEx) on nephrotoxic rats. Two main groups of forty adult male albino rats were created. Group 1 control (-) (n=5) and was fed the basal diet (B.D.). The second main group, (n=35), was split into seven groups with five rats each after receiving gentamicin injection to cause nephrotoxicity; group (2): As control (+) fed on B.D., groups (3 and 4): Fed on B.D. Containing (2 and 4 %) of ARP; groups (5 and 6): Fed on B.D. and orally administered with (200 and 400 mg/kg/B.W.) of ARAEx and groups (7 and 8): Fed on B.D. and orally administered with (200 and 400 mg/kg/B.W.) of AREEx, respectively. At the end of the experiment, serum was analyzed for kidney functions, liver functions, lipids profile (sodium, potassium), (HB, WBCs, RBCs, and PLT), glucose, immunoglobulin (IgG, IgA, and IgM), and urine was collected for 24 hours to determine (sodium, potassium, Total protein, and creatinine). According to the results, rats' kidney, liver, immunoglobulin, and lipid profiles were all enhanced better with oral AREEx (400 mg/kg/B.W.). In conclusion, rats handled with AREEx (400 mg/kg/B.W.) showed improved kidney functions, immunomodulatory activity, and histological structure of kidneys through their antioxidant and radical scavenging activities.

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