Biochemical and nutritional studies of Saw Palmetto (Serenoa Repens) in male albino rats suffered with fertility and immunity dysfunction induced by cadmium chloride

Document Type : Original research articles

Authors

1 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

2 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt.

Abstract

This study aimed to investigate the effect of saw palmetto on the fertility and immunity indices in male Albino rats suffering from fertility and immunity dysfunctions. 
 
Thirty-six adult male albino rats were used in this study and divided into six groups. 
 
The first
 major group was represented by the negative control group (n=6), which fed a basal diet. The second groups (n=30) were injected intraperitoneally by (CdCl2) 0.1 mL/100g body weight to infect infertility rats, then divided into five subgroups (n=6 in each). 
 
The first
 subgroup represented the positive control group, while the other groups were fed a basal diet supplemented with saw palmetto powder 3%-5% and water extract 3%-5%. The feeding course was carried out for up to 28 successive days. 
 
At the end of the experiment, blood samples were collected from each rat to estimate serum levels of Follicle-stimulating hormone, Luteinizing Hormone, and testosterone hormones. 
 
Immunoglobulins
 (IgG, IgM, and IgA) titer and serum liver and kidney enzyme function were determined. 
 
Obtained data indicated that both testosterone and LH hormone levels increased with water extract by 5%. FSH hormone level was decreased with water extract 5%. There was a significant increase in immunity indices and a decrease in liver and kidney enzymes. 
 
The histological
 structure of the testis was clearly improved, which reflects the powerful therapeutic effect of feeding on saw palmetto powder and their water extract for improving fertility and immunity in rats. The most potent result was obtained at 5% water extract of saw palmetto.

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