Protective and Curative Effect of Costus Roots on Hepatotoxicity in Male Albino Rats

Document Type : Original research articles

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Dept of Nutrition and Food Sciences, Faculty of Home Economics, Helwan University, Cairo, Egypt

Abstract

The purpose of this study was to ascertain the impact of costus (CS roots powder concentrations2.5% and 5% on the hepatotoxicity of male albino rats. Forty-two male albino rats were employed in the experiment. The rats were separated into seven main groups, including omit it curative and protective groups, after being fed the optimal diet for one week (six rats omit it each). Therapeutic teams: Group 1 was served a basal diet as the negative control group. Group 2 was a positive control group that received a basal diet along with three weekly injections of carbon tetrachloride (CCl4) (1 mg/kg body weight) to cause hepatotoxicity. The group (2) plus 2.5% (CS) powdered roots was fed to the third group. Group (4) was fed the same as group (2) plus 5% (CS) powdered roots. Defense Organizations Group (1)'s curative group and negative control group were similar. After eight weeks, the group (5) positive add the control group was given a basal diet plus a CCl4 injection (1 mg/kg body weight). The group (5) plus 2.5% (CS) powdered roots was fed to the group (6). The group (7) received the group (5) plus 5% (CS) powdered roots. Phytochemical analysis for costus roots was determined. The investigation documented that providing hepatotoxicity CS root powder at 2.5% and 5% in the curative add and protective groups increased body weight gain, feed intake and feed efficiency ratio. Our results could be add as follows: diets enriched with 2.5% and 5% CS roots powder improved blood lipid levels and reduced kidney and liver function risks.

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