Protective Effect of Nettle (Urtica dioica), Leaves and Seeds on Kidney Disorder in Gentamicin-Induced Rats

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.

Abstract

The influence of various concentrations of 2.5 and 5 % of nettle leaves, seeds, and their mixes as powder on gentamicin-induced renal disorder in male rats was investigated. Forty-eight albino rats, weighing about 150±10 g, were used and divided into 8 equal groups; the first one was kept as a negative (-ve) control group, while the other 7 groups were injected with gentamicin at the dose of 100mg/kg body weight for 10 consecutive days. When the experiment ended, renal functions, including serum uric acid, creatinine, and urea, lipid fractions consisting of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), and high-density lipoprotein (HDL-c) levels, serum glucose, and liver enzyme activities such as ALP, AST, and ALT, which were measured. The data was analyzed using [specific statistical analysis method]. From the obtained results, it may be stated that the best values for protection, improvement of renal functions, liver functions, lipid fractions, and glucose ranges were reported at a 5.0% mix of nettle leaves and seeds powder. In conclusion, we could utilize nettle leaves and seeds and their combined powder in our regular beverages, demonstrating the potent nutraceutical therapeutic advantages of consuming them separately and together for treating renal disorders

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