Document Type : Original research articles
Authors
1
Dept. Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
2
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
Abstract
This study discusses the potential therapeutic effects of alfalfa (Medicago sativa, L) ethanolic and aqueous extracts on oxidative / antioxidative status in diabetic rats. Thirty adult male albino rats weighing 150±10g, were used and distributed into two main groups. The first group (5rats) was given a basal diet as control (-), the second main group (25 rats) injected with alloxan to cause diabetes, then distributed into five subgroups. One of them was positive diabetes control. Compared to the various four groups, who consumed a basal diet and administered ethanolic and aqueous extracts of alfalfa at (200 and 400 mg/kg) orally, for 28 days. When the experiment was complete, after treatment with alfalfa extracts, the rats were weighed and slaughtered, blood samples were taken, the serum was separated to do the required measurements. Each body weight gain, feed intake, and feed efficiency ratio were calculated. While blood serum glucose, lipide profile, liver function markers, kidney function levels, oxidative enzymes such as catalase, super oxide dismutase and malondialdehyde were estimated. The obtained results showed that the intake of alfalfa extracts led to a significant improvement in both body weight gain and feed intake, feed efficiency ratio (FER), liver and kidney functions, sugar, and an increase in the percentage of high-density lipoprotein (HDL-c), catalase (CAT), and superoxide dismutase (SOD) at (P<0.05) compared to the positive control group. Therefore, the results recommended the use of alcoholic alfalfa extract at a concentration of 400 mg/kg in our regular diets because the active ingredients in alfalfa are beneficial for diabetics.
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