Document Type : Original research articles
Authors
1
Dept. Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
2
Department of Nutritiion and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
3
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
Abstract
Carbon tetrachloride (CCl4) is a toxic substance linked to liver damage and oxidative stress. So, the current study investigated the influence of pomegranate peel waste on minimizing the risk of CCl4 hepatotoxicity in rats. Thirty male albino rats were divided into two main groups. The first group ) was the negative control group (6 rats), fed on a basal diet for all experimental periods. The second group (hepatotoxic rats) (n=24 rats)was divided into four subgroups (6 per each group) .subgroup one served as the positive control group .subgroup 2, 3, and 4 were fed on 1.5, 3, and 4.5% of pomegranate peel powder respectively for 30 days. Subcutaneous injection of CCl4 produced a marked elevation (P < 0.05) in the serum levels of aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP), malondialdehyde (MDA), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDLc) and very low-density lipoprotein(VLDL). Treatments of 4.5% of pomegranate peel improved liver function, antioxidant status in liver tissues, and lipid profile compared to the positive control group. In conclusion, our results suggest that pomegranate peel has antihepatotoxicity and antioxidant properties in hepatotoxic rats by CCl4.
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