Potential Effects of Cake Incorporated with Stevia Leaves and Metformin in Diabetic Rats: A Comparative Study

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

The present study was designed to study the effect of cake incorporated with different levels of Stevia leaves (stevia rebaudiana) and metformin as ant hyperglycemic medication on diabetic rats. Thirty-six adult male albino rats were used in this study, weighting (150±10g) were divided into six groups, six rats each. Stevia leaves and metformin as powder were added at percent 2.5 % & 5% of the main diet and 250 and 500 mg/kg BW., respectively for 28 days. Diabetic rats were induced Alloxan subcutaneously injection (150 mg/kg body weight). Serum glucose, lipid profiles of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), and high-density lipoprotein (HDL-c), the activities of the liver enzymes ALT & AST, and the kidney functions of creatinine, uric acid, and urea levels were determined at the end of experimental. From the obtained results it could be concluded that consuming cake incorporated with stevia leaves and metformin caused significant (P≤ 0.05) decrease of serum glucose, liver enzymes activities, kidney functions and enhance of HDL-c, as compared with control (-ve) group. The best result was recorded for 2.5% cake incorporated with stevia leaves and metformin. As conclusion, consuming cake incorporated with stevia leaves and metformin as powder attenuated diabetic effects in rats, which reflects the powerful nutraceutical therapeutic effects.

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