Potential Ameliorative Effect of Melissa Officinalis Ethanolic Extract on Bleomycin-Induced Cardiotoxicity in Rats

Document Type : Original research articles

Authors

1 Home Economics Department, Faculty of Specific Education, Assiut University, Egypt

2 Faculty of science - Al-Azhar University - Assiut - Egypt

Abstract

Melissa officinalis has antioxidant and anti-inflammatory activities and is used in various diseases. This study aimed to elucidate the ability of Melissa officinalis ethanolic extract to lessen cardiotoxicity in male rats after being injected with bleomycin to infect them with cardiotoxicity. Forty adults male Wister albino rats weighing (150–200g) were placed into four groups at random after acclimatization (10 rats each); The first group, which functioned as the control group, was composed of healthy rats, the second group included ordinary rats orally administered with 450 mg/kg/day of Melissa officinalis extract (MEE) for six weeks, Rats in the third group were given bleomycin intraperitoneally at a dose of 15 mg/kg/week for the same duration, and the fourth group included rats poisoned with bleomycin for six weeks while being concomitantly ingested with MEE orally for six weeks. The findings showed that MEE significantly reversed the cardiological declines brought on by bleomycin; this was demonstrated by a large increase in cardiac GSH and CAT and a significant reduction in cardiac MDA. Additionally, despite increased HDL, serum levels of CK, LDH, TNF-α, IL-1β, cholesterol, triglycerides, and LDL have been significantly lowered. Additionally, the histopathology results demonstrated significant regrowth. In conclusion, MEE contains a high concentration of antioxidants like phenolic compounds that can decrease bleomycin-induced cardiotoxicity. So, these results recommend using Melissa officinalis as a food supplement as it effectively reduces cardiotoxicity.

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