The Impact of Ivy (Convolvulus arvensis L.) Leaves Extract on Biological Markers of Hyperglycemic Rats

Document Type : Original research articles

Authors

1 Dept. Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

2 Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University.

Abstract

The problem of hyperglycemia has grown to be a significant obstacle for worldwide health issues. Drug resistance to treatments for diabetes and cytotoxicity have caused scientists worldwide to turn their attention from artificial to medicinal herbs. The current investigation aimed to find out how Ivy leaves extract affected the biological markers of diabetic rats. Thirty male adult albino rats (150 ±10 g) were used and divided into five groups (6 rats each). The first group was kept as a negative control group and was given the basal diet, but alloxan injections were given to the other four groups to cause hyperglycemia; the second group was given only a basal diet and served as a positive control group, which as the other three groups received a daily oral dose of ivy leaves extract 50, 100, and 150 mg/kg B.W. The results of treated rats showed a decrease in relative organ weight, liver enzymes, kidney function, serum glucose level, and lipid profile. At the same time, BWG, F.I., FER, and HDL-c were improved by rising compared to the positive control group when ivy leaf extract 50, 100, or 150 mg/kg B.W. was administered orally. The Ivy leaves extract had the best results when used at 150 mg/kg B.W. Conclusion These findings support the extract's traditional usage in the treatment of diabetes by indicating that it contains bioactive substances that can lower persistent hyperglycemia while avoiding complications.

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