Effect of Gum Arabic and Khella Seeds in Treatment of Kidney Functions Defect in Gentamicin-Induced Rats

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.

Abstract

A decrease in renal function significantly impacts metabolism and nutritional status. Numerous plants have been found to possess antioxidant properties and protect against experimental renal toxicities. This study examined the effects of different doses of 2% and 4% of powdered mixes of gum Arabic (Acacia Senegal, L.) and Khella (Ammi visnaga, L.) on nephrotoxic rats. In this experiment, 48 white male albino rats weighing 140-150±10g were used. The rats were divided into eight groups. Each group contains six rats. Nephrotoxic was induced in normal healthy male albino rats by injecting 10 mg/kg body weight of gentamicin intraperitoneally once daily for ten days, while one was kept as the negative control group. The following data included glucose level, serum liver functions (ALT, AST, and ALP), markers of kidney functions (creatinine, urea, and uric acid), and lipid profile (total cholesterol, triglycerides, HDL-c, LDL-c, and VIDL-c). According to the results, rats' kidney, liver, serum glucose, and lipid profiles were all enhanced better with the combination of Gum Arabic and Khella seed powder. The best results were shown with the 4% mixture, which is advised for use as a beverage drink to improve kidney functioning. In conclusion: In treating rats with renal failure, Gum Arabic and Khella seeds can be considered potential therapeutic feeding programs.

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