Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences,Faculty of Home Economic, Menoufia University, Shibin El-kom, Egypt
2
Nutrition and Food Sciences Department, Faculty of Home Economics, Menofeya University, Shebin Elkom, Egypt
3
Nutrition and Food Sciences, Faculty of Home Economics, Menofeya University, Egypt
Abstract
This work aimed to study the effect of loquat leaves and fruits on hypercholesterolemic rats. Thirty-six adult male Sprague Dawley rats were divided into two main groups; the first group was the control negative (-C; n=6), and the other second groups were administered orally (hypercholesterolemic rats) and were divided randomly into five sub-groups (Control positive +C). Groups (G3 & G4) were fed a basal diet supplemented with loquat leaves (4% and 7%, respectively). Groups (G5 & G6) were fed a basal diet supplemented with loquat fruits (4% and 7%, respectively). After 28 days of feeding, the rats were sacrificed, and their serum was collected. Samples. Serum lipids profile and enzyme activity of the liver and kidneys were determined. Hypercholesterolemia caused a significant decrease in HDL-c while a significant increase was recorded in BWG, FI, FER, TC, TG, VLDL-c, LDL-c, uric acid, creatinine, urea, AST, ALT, ALP, and glucose. Hypercholesterolemic rats treated with various diets showed improvement in all previous parameters, especially 7% loquat leaves. In conclusion, rats treated with supplemented7% loquat leaves improved lipid profiles and kidney function; therefore, such leaves are highly recommended for helping with hypercholesterolemia; however, many more human studies are needed.
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