Effect of Biscuits Fortified with Pumpkin, and Sunflower Seeds, on Alloxan-Induced Diabetic Rats

Document Type : Original research articles

Authors

1 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.

2 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

Edible seeds have been used to reduce the symptoms of diabetes because they contain natural antioxidants that can protect cell function caused by diabetes. This study aims to investigate the effect of biscuits fortified with pumpkin and sunflower seeds and metformin (antihyperglycemic medication) on diabetic rats. Eight groups of six adult male albino rats, each weighing (15010g), were used in this study. For 28 days, biscuits fortified with pumpkin and sunflower seeds and metformin were gradually added to the basal diet at a rate of 2.5 and 5 %, and 250mg/kg, respectively. Alloxan (150 mg/kg body weight) was injected subcutaneously into diabetic rats. At the end of the experiments, serum glucose levels, lipid profiles of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), and high-density lipoprotein (HDL-c), the activities of the liver enzymes ALT & AST, and the kidney functions of creatinine, uric acid, and urea levels were evaluated. The results indicated that consumption of biscuits fortified with pumpkin and sunflower seeds, as well as metformin significantly (P≤0.05), improved the level of glucose in the serum blood of rats, increased HDL-c significantly, and improved liver and kidney functions by decreasing ALT, AST, creatinine, uric acid, and urea in the rats compared to the positive group. In conclusion, the most significant thing to add is biscuits fortified with pumpkin and sunflower seeds to our snack diet to reduce glucose in the blood.

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