The Protective Effects of Carob Seeds in Hepatotoxic Rats with Liver Dysfunction

Document Type : Original research articles

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Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

Abstract

The second-largest organ in the human body is the liver. Numerous causes might harm the liver, including genetic conditions and environmental toxins. Because of its numerous pharmacological advantages, carob is a plant with significant relevance in traditional medicine. The current investigation aimed to determine that carob seeds (Ceratonia silique, L.) in powder and aqueous extract affected CCl4-induced liver damage in rats. In this investigation, thirty mature male albino rats weighing (150±10g) were divided into six groups with five rats each. The (+ve) group and the other four groups were fed the food plus 0.2 ml/100 g body weight of 40 ml/l CCl4 for 14 days to induce liver fibrosis, while one of them was kept as a control (-ve) group. Carob seeds (powder and aqueous extract) were introduced to the main diet at 5 and 10%, respectively. Body weight gain, food intake, feed efficiency ratio, glucose level, renal function tests (creatinine, uric acid, and urea levels), serum liver enzymes (ALT et al.), and lipid profile (TG, TC, HDL-c, LDL-c, and VLDL-c) have all been determined. According to the results, eating carob seeds (powder and aqueous extract) increased HDL-c levels significantly (P≤0.05) but also significantly decreased body weight gain compared to the control (+ve) group, improved liver and kidney functions, and returned serum glucose and blood lipid levels to normal, reflecting the potent nutraceutical therapeutic effect for eating carob seeds (powder and aqueous extract).

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