Nephroprotective Effect of Clove (Syzygium aromaticum) Extract on Carbon Tetrachloride Induced Nephrotoxicity in Albino Rats

Document Type : Original research articles

Authors

1 Department of Home Economics, Faculty of Specific Education, Assiut University, Assiut, Egypt

2 Zoology Department , Faculty of Science, Al-Azhar University, Assiut, Egypt

Abstract

Exposure to carbon tetrachloride (CCL4) inhibits acute and continual renal injuries besides oxidative stress in rats. The present investigation was carried out in an attempt to assess the nephroprotective potential of clove (Syzygium aromaticum) extract (CE) towards CCL4 precipitated nephrotoxicity. Forty adult male  Wister albino rats weighing 140-180g  and divided into four groups, each group (10) rats. Group (1): normal rats served as the negative control group; group (2):  rats implemented with CE  (50 mg/kg/day) orally; group (3):  rats injected with CCL4 (0.5 mg/kg/ two times weekly) intraperitoneal,  and group (4):  rats inflamed with CCL4 and treated with CE. After six weeks,  the results revealed that CE and CCL4 minimized the  CCL4-induced  renal deterioration; this was evidenced by the significant reduction in urea,  creatinine,  uric acid,  TNF-α,  IL-1β, and  Na, as well as kidney MDA. This is matched with a marked enhancement in serum calcium, K, and CD4 levels and kidney GSH and CAT levels. In conclusion, Clove (Syzygium aromaticum) extract can be as promising as nephroprotection in opposition to CCL4 nephrotoxicity through their antioxidant and radical scavenging activities.

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