Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences, Faculty of Home Economics, Helwan University, Cairo, Egypt
2
Department of Agriculture Pesticides., Faculty of Agriculture, Mansoura University, Mansoura, Egypt.
Abstract
The present study was designed to determine the modulating effect of Green tea at different doses against adverse effects of malathion. Rats were divided into seven groups (5 rats /group). Group one was used as a control group control(2,3) and given malathion (50 mg/kg/day and 200mg/kg/day, respectively, for four weeks), and group four was given malathion (50 mg/kg/day and Green tea 200mg four weeks), Group five were given malathion (50 mg/kg/day and Green tea 400mg four weeks), Group six were given malathion (200 mg/kg/day and Green tea 200mg four weeks), and Group seven were given malathion (200 mg/kg/day and Green tea 400mg four weeks respectively. The experiment continued for four weeks, then rats fasted, and blood samples were collected for biochemical analysis. The results showed that the malathion-treated group had significantly higher serum Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), urea, creatinine, uric acid, low-density lipoprotein (LDL), Very low-density lipoprotein (VLDL), Triglycerides (TG) and Cholesterol (CHOL) levels than the control group and the malathion-treated group had significantly lower Body Weight Gain (BWG), feed intake(FI) and feed efficiency ratio (FER), High-density lipoprotein (HDL) levels than the control group. In conclusion, green tea can ameliorate the liver and kidney deterioration caused by malathion among experimental rats.
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