Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt
2
Department of Nutrition and Food Sciences,Faculty of Home Economic, Menoufia University, Shibin El-kom, Egypt
3
Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shibin ElKom, Egypt.
Abstract
Egypt is among the world's top 10 countries in the number of patients with diabetes. Medicinal plants are used to treat diabetes to overcome hypoglycemic medications' cost and unwanted side effects. The current study investigated the potential effects of curry and walnut leaves powders (CLP&WLP) and their methanolic extracts (CLEx., &WLEx.) on diabetic rats. Sixty male albino rats weighing (150±10g) were divided into two main groups. First main group (6 rats): as control (-ve) fed on the basal diet BD. Second main group (diabetic rats 54 rats): was injected with alloxan to induce DM and divided into nine subgroups, six rats for each as follows: group (2): as control (+ve) fed on BD, groups (3-6): fed on BD containing (5.0 and 7.0 % (w/w) of CLP &WLP) and groups (7-10): fed on BD and orally administered by (200 & 400 mg/kg. bwt/d of CLEx. &WLEx.), for 42 days respectively. Results showed that diabetes-induced a significant (P≤0.05) decrease in insulin, HDL-c, Superoxide dismutase (SOD), Glutathione peroxidase (GPX) & Catalase (CAT) activities, and significantly increased blood glucose level, liver & kidney functions parameters, lipid profile and malondialdehyde content (MDA). Treatment of diabetic rats with CLP, WLP, CLEx, and WLEx., at the different concentrations led to improvements in all of the above parameters. In conclusion, these discoveries provide a basis for the use of curry and walnut leaves for the prevention/treatment of DM instead of/beside the artificial medicines that might have undesirable aspect effects.
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