Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.
2
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
Abstract
Costus and Bitter melon are medicinal plants that produce a variety of chemical compounds that are useful in the treatment of various diseases, including obesity. This study aims to determine the efficacy of Costus and Bitter melon in reducing obesity in obese rats. Forty-eight male albino rats weighing 150g±10g were divided into eight groups, each with six rats. To induce obesity in rats, a high-fat diet (20 % sheep fat) was fed to them. The research also measured glucose levels, liver functions {Alanine aminotransferase (ALT) & Aspartate aminotransferase (AST)}, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL-c), atherogenic index (AI) and kidney functions (urea, uric acid, and creatinine). The findings revealed that the treated groups exhibited lower glucose levels, liver functions, and kidney functions, especially when fed 5% Costus and Bitter melon, with significant differences (P<0.05), lowest TC and TG levels, as well as the lowest LDL-c, VLDL-c, and AI values, and vice versa in HDL-c levels. In conclusion, obese rats fed a 5% mixture of Costus, and Bitter melon powder showed improved lipid profiles, glucose levels, liver function, and renal function. Therefore, the study suggests using Costus and Bitter melon in the recommended proportions to reduce the levels of obesity in the body.
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