Document Type : Original research articles
Authors
1
Faculty of home economics department of nutrition and food science menofia university
2
Department of Nutrition and Food science, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt
3
Department of Physiology, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt.
Abstract
This work aimed to study the effect of Chicory (Cichorium intybus; C. intybus roots on kidney functions in male albino rats. Forty adult male Sprague Dawley rats were divided into two main groups; the first was the control negative (C-; n=8), and the rest were injected with gentamicin for kidney failure induction. The second group was divided randomly into four sub-groups (Control positive C+) and three more groups (G3:G5) fed on a basal diet supplemented with powdered chicory roots (2.5, 5, and 7.5%, respectively). At the end of the experiment, body weight gains (BWG) and collected blood serum samples were analyzed for serum glucose levels and lipid profile (cholesterol, triglyceride, HDL, and LDL) in addition to kidney functions (Creatinine, Creatinine clearance Urea, and Uric acid). The collected data showed that gentamicin injection caused significant decreases in BWG, FI, FER, and HDL, while significant reductions were recorded in Urea, Uric acid, cholesterol, triglyceride, LDL & VLDL after the consumption of the studied root, especially at 5% supplementations. In conclusion, rats treated with supplemented chicory roots at 7.5% showed an improvement in kidney function and lipid profiles; therefore, such roots are highly recommended for helping with kidney disease; however, many more human studies are needed.
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