Document Type : Original research articles
Authors
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt.
Abstract
This study aimed to investigate the effect of Garcinia cambogia (G.C.) peels powder and extract (GCE) on obese rats. Thirty male adult albino rats (weighting 140 ±10 g) were divided into two main groups, the first (5 rats) functioning as a negative control. The second major group (25 rats) fed on a high-fat diet (20% animal fat) for 28 days to produce obesity, after which they were divided into five groups (5 rats each), one of which was kept as a positive control group, while the other four were given G.C. powder 0.5%, G.C. powder 1%, G.C. powder 1.5% and GCE (250 mg\kg). At the end of the experiment period of 28 days, body weight gain, feed intake, and feed efficiency ratio were evaluated. Also, blood samples were analyzed for determination of serum liver enzymes (AST, ALT & ALP), serum lipid profile (T.G., T.C, LDL-c, HDL-c &VLDL-c), and kidney functions (uric acid, urea & creatinine). Obesity led to a significant (P ≤ 0.05) increase in BWG, F.I., FER, T.C., T.G., VLDL, LDL, uric acid, urea, creatinine, AST, ALT, ALP, and glucose, while a significant (P ≤ 0.05) decrease in HDL. Feeding on G.C. powder and extract reversed this effect. Finally, results indicated that the best group was recorded for (G5) (1.5% G.C.) and (G6) (250mg\kg GCE). Therefore, it is recommended to use them as effective treatments in reducing the accumulation of harmful fat in the body and reducing weight.
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