Anti-Diabetic Effect of Neem (Azadirachta indica,) Leaves of Alloxan-Induced Diabetic Rats

Document Type : Original research articles

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1 Department of Nutrition and Food Science, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

2 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.

Abstract

The traditional medicinal herb neem (Azadirachta indica) may contribute intriguing bioactive compounds to the present diet in many countries. Herbal substances are being used as medicinal agents. This study evaluated the effects of different concentrations of neem leaves powder 2.5 and 5% and ethanolic extract 250 and 500 mg/kg b.w. on diabetic rats. Thirty-six white male albino rats weighing 140±10g were utilized, divided into six groups of six rats each. Diabetic rats were infected with alloxan (150 mg/kg body weight). The following tests were performed: glucose, serum liver functions (ALT, AST, and ALP), T.G., T.C., LDL-c, HDL-c, VIDL-c, and kidney functions (urea, uric acid, and creatinine). HPLC was also used to determine the phenolic components in neem leaves. The findings showed that rats given neem leaves powder or extract improved their serum glucose levels, liver functions, kidney functions, and lipid profile. The best results were obtained with 500 mg/kg neem leaf extract. As a result of the findings, it is suggested that neem leaves contain numerous phytochemicals and can be used as an antioxidant to lower glucose levels in diabetic rats. Apart from the fact that it offers numerous health advantages.

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