Document Type : Original research articles
Authors
1
Department of Nutrition and Food Sciences, Faculty of Home Economics, Helwan University, Cairo, Egypt.
2
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menofia University, Shibin Elkom, Egypt
3
Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El-Kom, Egypt.
Abstract
Osteoporosis is a major health disease that affects people all over the world. It happens when there is a considerable of bone loss and it's linked to a higher risk of fracture. The goal of this study was to see how calcium, vitamin D, and chia seeds affected rats with osteoporosis. In this study, 48 female albino rats (Sprague Dawley strain) weighing an average of 200g±10g were divided into eight groups. Throughout the experiment, the negative control group was fed a basic diet. The experimental groups, which included 42 rats, received oral prednisone acetate (4.5ml/kg body weight/day twice a week) rats fed on a 5 percent chia, 1 percent calcium, and 400mg vitamin D diet treated rats with osteoporosis at groups 3,4,5,6,7, and 8, received oral prednisone acetate (4.5ml/kg body weight/day twice a week) rats fed on a 5 percent chia, 1 percent. The results showed that prednisone acetate treatment resulted in a significant (P≤0.05) increase in serum total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-c), very low-density lipoprotein-cholesterol (VLDL-c), glucose, and liver enzymes (AST, ALT, and ALP), as well as a decrease in high-density lipoprotein–cholesterol (HDL-c) concentration. These measures were markedly enhanced for osteoporotic rats treated with 5% chia, 400mg vitamin D, and 1% calcium. Calcium, phosphorus, BMD, and BMC levels enhanced in osteoporotic rats treated with 400 mg vitamin D and 5% chia. As a result, determining risk and treatment recommendations requires a thorough understanding of the systems that regulate bone health.
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