Effect Of Jew’s Stone Alone Or In Herbal Formulations On The Renal Dysfunction

Jew’s stone is useful for renal health as it expels kidney’s stones. As reported in folk medicine a small amount of Jew’s stone was claimed to be useful for curing of the urinary bladder stones which requires for scientific confirmation. Herbal formulae of Burdock, Ginkgo, Juniper, Corn Silk, Rosemary, Nettle, Fennel, Thuja and Sweet Majorana were studied in present work on renopathic rats as possible enhancement of Jew’s Stone action.
Twenty-four adult male albino rats, Sprague – Dawley strain, weighting (150 ± 10g) were used and fed on diets containing Jew’s stone diet with and without the herbal collections for 28 days. The rats sacrificed and serum analyzed.
The results arrived to be summarized as follows:
Feeding on basal diet contained Jew’s stone with and without herbal collections raised the BWG and FER. Inflicting with renopathy raised the internal organ weight while the reverse indicated on feeding with Jew’s stone with and without herbal collections. Due to renopathy, rat’s serum glucose level was raised, but when feeding on basal diet contained Jew’s stone with and without herbal collections serum glucose decreased. Treatment with Jew’s stone + herbal collection 2 in group 5 (Nettle, Juniper & corn silk) recorded the highest decrement. Gentamicine injection increased total Cholesterol, T.G, LDL & VLDL, but decreased the serum HDL.
The best serum HDL was observed in group 5 which fed on Jew’s stone + herbal collection 2 (Nettle, Juniper & corn silk) when compared with group 2 (control +ve).  Maximum improvement of serum creatinine, urea & uric acid was found in group 5 Jew’s   stone + herbal collection 2 (Nettle, Juniper & corn silk). Due to nephritis rats urine Na &K were decreased, while were increased in serum. Nevertheless feeding on diets contained Jew’s stone with and without herbal collections reversed the changes due to renopathy.
Rats fed on Jew’s stone + herbal collection 2 (Nettle, Juniper & corn silk) in group 5 indicated the best treatment for correcting urine Na &K levels.
Rats fed on Jew’s stone + herbal collection 2 (Nettle, Juniper & corn silk) in group 5 indicated the best treatment for correcting serum Na &K levels.
Due to nephritis creatinine clearance were decreased, while maximum improvement of creatinine clearance was found in group 5 Jew’s stone + herbal collection 2 (Nettle, Juniper & corn silk). Inflecting with renopathy raised the activities of serum AST & ALT while feeding Jew’s stone with and without herbal collections reduced these levels. The best treatment to correct the levels of AST & ALT enzymes was observed in group V which fed on Jew’s stone + herbal collection 2 (Nettle, Juniper & corn silk).
Due to nephritis serum protein & albumin were decreased, while the increase was recorded in serum globulin. Nevertheless feeding on diets contained s with and without herbal collections reversed the change due to renopathy. The maximum improvement of serum total protein & albumin were found in group V which fed on Jew’s stone + herbal collection 2 (Nettle, Juniper & corn silk).