ANTI INFLAMMATORY EFFECT OF SELECTED DIETARY ANTI OXIDANTS

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          In this study forty five normal male albino rats of Sprague Dawley strain, Weighting (140+_5g) were used to study paw edema . In order to carry out the study a formalin 1.0 mg/kg- induced  the  paw edema model in rats .The period continued 21 days from  the date of injury .The regular  intake of different concentrations (5,10 mg/kg) of 5or 10% tomatoes, spinach , Jew’s  mallow(Corchorus olitorius )and n-acetyl cysteine,(NAC) in dietshas been associated with a reduced  risk of  paw edema . Inflammation was assessed by the measurement of paw volume  after 0,1,2,4,5h and4,6,8,12.19.21 day, of  injection , Complete Blood Count(CBC),some of liver function parameters and  malondialhide (MDA) were determind. Spinach at 10% showed significant reduction of paw edema after 6 days of  formalin  injection .Likewise poth of  tomato at  5%and Jew’s  mallow at 10% showed significant reductions of paw edema after 8 days of formalin injection. Also spinach at 5% showed significant reduction of paw edema after 12 days of formalin till the end of experiment. NAC,tomato and spinach( 5%) induced  significant decreases in glutamate pyruvate transaminase( GPT).All plants induced significant decreases in MDA level . Tomato and spinach at (5 and 10%) caused decreased in platelet cell (PLT) levels. Also tomato 5%, spinach10% and Jew’s mallow 5% induced significant decreases in lymphocytes level. The present results showed that the mentioned plants has anti inflammatory activity on paw edema .It could be speculated   that administration might be useful in the pharmacological modulation of inflammatory changes.

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