Biological Study of the Protective Effects of Fennel, Chamomile and Cardamom Oils Against Aspirin Induced Gastric Ulcers in Male Albino Rats

The present study is conducted to investigate the effect of protective effects of fennel, chamomile and cardamom oils against Aspirin Induced Gastric Ulcers in Male Albino Rats. Forty two male albino rats were classified into normal control group and five aspirin induced gastric ulcer groups. The results revealed that, the treatment with these oils can protect from aspirin induced gastric ulceration. The mechanism of its gastro protective activity may be attributed to significant reduction in volume of gastric juice, total acidity of gastric juice, gastric ulcer index, serum total oxidative capacity , serum interleukin-1 IL-1, serum tumor necrosis factor-alpha, gastric COX-2 activity and gastric total nitric oxide concentration  along with significant elevation in serum total antioxidant capacity , blood hemoglobin, gastric prostaglandin PGE2 level and gastric cytochrome P₄₅₀ reductase activity compared with ulcerated control (+ve) group. Curative ratio percentage showed insignificant difference of oils treatment groups compared with RAN drug group. These obtained results are confirmed by the histopathological examination. The protection afforded by treatment of fennel  , Chamomile and Cardamom oils was found to be effective. In conclusion, the fennel  , Chamomile and Cardamom oils possess antiulcer potential due to its antioxidant and anti-effect. The healing activity may be due to its cytoprotectivity effect coupled with anti-secretory activity.