Studying The Effect Of Leaves And Seeds Powder Of Carica Papaya At Two Doses On Hyperuricemic Of Experimental Animals

Hyperuricemia is a primary risk factor for the development of gout. A Carica papaya fruit is a source of nutrients such as provitaminA carotenoids, vitamin C, folate and dietary fiber, pulp and seeds also contain a variety of phytochemicals, including lycopene and polyphenols. The current research study the effect of seeds and leaves of Caricapapaya at two different concentrations (5 and 10%), on level of Hyperuricemia between healthy and hyperuriecemic rats. Thirty sixmale albino rats weight 150±10g divided into six groups (+ve), (-ve), (5 and 10%) leaves and seeds powder.Hyperuricemic induced by alcohol(2 g /kg of body weights every 24 hours)for six days.Food intake (FI), body weight gain and organs weight were recorded. Furthermore, Biochemical analysis of serum; urea, creatinine, uric acid, total protein, albumin, globulin, A/G ratio, AST, ALT, total cholesterol, triglyceride, HDL-c, LDL-c, and VLDL-c were determined. Both seeds and leaves caused an increase in the body weight for both used concentrations. However used leaves at 5% raised FI between in all the studied groups. On the other hand, kidney weight shows no effects between all the groups in both leaves and seeds although there is an increase in the liver weight for both leaves and seed 10, 5%, respectively. Surprisingly, all the determined urea levels in all the studied groups decreased; however, seeds with 10% were the highest reduction among all groups. Uric acids significantly decreased at level 10% in seed powder, there were a significantly decreased in serum ALT and AST at two levels for leaves and seeds powder. Seeds powder at two doses caused a decrease in total protein and globulin while, in serum albumin was increased significantly at two levels. Leaves powder at 10% and seeds at two doses cause a decrease in serum total cholesterol and serum triglycerides. Serum HDL was significantly increased while, serum LDL was decreased. Consumption Carica papaya seeds or leaves caused improvement benefits in health status.