Biological studies on green coffee beans extracts and its relationship with obesity and diabetes mellitus diseases

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This study was conducted to investigate the effect of green coffee beans consumption on obesity and diabetes mellitus diseases. Twenty five Albino rats weighting (190 ±20 g) were divided into 5 equal groups, one was kept as a control-Ve group, While the other 4 groups were injected by alloxan after induction of obesity.  Obese diabetic rats were  fed  orally with green coffee extract (10-20%) by the dose 4mg.day-1. Serum liver enzymes activities (ALT, AST and ALP), kidney function parameters (creatinine and urea levels), serum lipid profiles (TG, LDL-c and HDL-c), serum lipid oxidation parameter (TBARS) and glucose level were examined. The obtained results revealed that green coffee beans extract, contains several classes of phytochemicals with other compounds, are able to prevent or inhibit obese and diabetes complications through liver serum enzymes-lowering activity, kidney function parameters concentration lowering, enhancing the serum lipid profile and decreasing rate on the formation of TBARS in serum. In conclusion, data of the present study recommended green coffee extract by a concentration 4 mg.day-1 %, amount to be included in our daily diets, drinks and food supplementation

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