Effect of Adding Lipoic Acid to Ameliorate the Flaxseed Oil for the Treatment of Rats with Hyperlipidemia

Document Type : Original research articles

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1 Department of Nutrition and Food Sciences, Faculty of Home Economics, Menoufia University, Shibin El Kom, Egypt

2 Department of nutrition and food sciences, Faculty of Home Economics, Menoufia University, shibin El Kom, Egypt

Abstract

Hyperlipidemia is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and α-lipoic acid (LA) have been reported to exert potential benefits to the  cardiovascular system. This study tried to assess The effect of adding lipoic acid to ameliorate Flaxseed oil for the treatment of rats injured by hyperlipidemia on the hyperlipidemia risk factors in rats fed a high-fat diet. The effect of adding lipoic acid to a meliorate Flaxseed oil for treatment the rats injured by hyperlipidemia. LA was dissolved in flaxseed oil with different concentrate lipoic acid (6%, 9%, 12%) and flaxseed oil 25% to rats in addition to the main food for 28 days, Thirty male albino rats weighing 150-160 grams were used in this study and were divided into 6 equal groups, each group contained 5 mice, the first group was kept as a positive control and the second group was kept as a the negative control while the other groups were fed on Diet for 4 weeks flaxseed oil and (tested) lipoic acid (P≤0.05) decreased serum lipids, serum VLDL, HDL and AI. also improve liver and kidney functions. The hypothesis of the obtained results in which flaxseed oil and lipoic acid were tested contain several compounds capable of ameliorating the adverse effects and inhibition of hyperlipidemia rats. FO and LA supplementation may contribute to the reduction of hyperlipidemia by improving the plasma lipid .

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