Effects Of Stevia (Stevia Rebaudianabertoni) And Debettered Stevia Extracts On Hyperglycemic With Hepatotoxicity In Rats.

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Stevia, a natural sweetener plant having medicinal and commercial importance is being used all over the world. This study aimed to evaluate the effect of stevia and stevia after remove its bitterness to ameliorate the adverse effects hyperglycemic with hepatotoxic rats. Different β-galactosidase enzyme concentrations 1, 2, 3, 4 and 5% were added to stevia aqueous extract to remove its bitterness. Stevia leaves extract treated by 5% β-glycosidase enzyme was the best treatment. Instant coffee was prepared by added table sugar, dried stevia aqueous extract (DSAE), dried debettered steviaaqueous extract by β-galactosidase enzyme (DDSAE) and aspartame then sensory evaluation showed DDSAE was improve sweetness, bitterness and overall acceptability compared other additives. Forty adult rats were randomly divided into two main groups, the first group, negative control group (n=8), and the second group: hepatotoxic diabetic groups (n=32) fed standard diet and were divided into four sub groups (8 rats/each), subgroup1: positive control group and sub group 2,3 and 4 received a daily oral dose of 400 mg/kg B.W/ day of dried DSAE, DDSAE and aspartame respectively. The results indicated that rats treated withDSAE and DDSAE were significant (P≤0.05) decreased in the level of blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (T.Bill), improved antioxidant status and weights gain, but DSAE were more effective.In conclusion, the treatment with stevia had the ability to decreasing of blood glucose, lipid oxidation and improving liver functions of hepatotoxicdiabeticrats

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