Anti-diabetic Effect of Persimmon (Diospyros kaki) Fruits in Alloxan-Induced Diabetic Rats

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The effect of different concentrations (5,7.5 and 10%) of persimmon fruits (Diospyros kaki) on diabetic rats were evaluated. Thirty rats were used in this study and divided into 5 groups, each group contain 6 rats. Rats were treated by aloxan (150mg/kg B.W) to induced diabetic. Results showed that the highest body weight gain, feed intake and feed efficiency ratio recorded for 10 % persimmon fruits, while the lowest recorded for 5 % persimmon fruits with no significant difference between persimmon treatments.Rat groups fed on 10% persimmon fruit recorded the highest liver, kidney and spleen weight. Rats fed on 10 % persimmon recorded the lowest glucose level with significant differences being, 97.53 mg/dl. The lower ALT and GOT liver enzyme of treated group which recorded for group fed on 10 % persimmon fruits, but the highest value recorded for group fed on 5 % persimmon fruits with significant difference. The highest GPT liver enzyme of treated group which recorded for group fed on 7.5 % persimmon fruits. Lowest value of triglyceride and cholesterol recorded for group fed on 10 % persimmon fruit. The highest HDL-c of treated group recorded for group fed on 10 % persimmon fruits. While, the highest LDL-c and VLDL-c of treated group recorded for rats fed on 5 % persimmon fruits. The highest urea and uric acid levels of treated group which recorded for group fed on 7.5 % persimmon fruits. While, the highest creatinine level of treated group which recorded for group fed on 5 % persimmon fruits.

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