The use of dietary antioxidants to improve on CCl4 hepatotoxicity rats

Document Type : Original research articles

Authors

Abstract

Liver disease still a medical problem that face several patients in awide as especially large base of humans. Liver injury due to chemicals (or) infectious agents may lead to progressive liver fibrosis and ultimately cirrhosis and liver failure.Therefore the aim of this study was to investigate the protective effect of four plants  including green coffee, Red cabbage, Artichoke, Black mulberry and silymarin individually toward hepatotoxicity induced by CCl4. All plants were added at two concentration levels, 2.5 % and 5 %, respectively to the basel diet. Forty-eight adult male albino rats, weighing ( 150±5g ), were divided into 12 groups each with 4 rats, each with similar total body weight. All the group of rats except for negative control were injected for two consequence weeks each with 0.2mg/kg of Carbon tetrachloride (CCl4) injectable solution to induce the liver impaired. Glutamic Oxaloacetic transaminas (GOT),glutamic pyruvic transaminas (GPT), creatinine, and histopathological changes all were measured. The results showed that all treatments significantly reduced Glutamic Oxaloacetic transaminas (GOT) as compared to positive control grop (p≤ 0.05). Treatment plants were order upon their effects on GOT values as following: blackmulbarry 5% >  silymarien 5%> silymarien 2.5%> red cabbages 5%> artichoke 5%. On the other hand, their treatment plants were order upon their effects on GPT values as following: silymaren 5% > red cabbage 5%> green coffee5%>artichoke5%>  silymaren 2.5%> Black mulberry 2.5%.data also showed that all treatment plants were order upon their effects on GSH values as following: silymaren 5% > red cabbage 5%> artichoke 5%> silymaren 2.5%> Black mulberry 2.5%. Significant increase in creatinen on control positive grope as compeard with control negative.  Histopathological investigation confirmed the biochemical changes in the liver and spleen functions. In concolusion, data suggested a potential role of these plant under study on liver diseas

Keywords

Main Subjects

Files

Share

How to cite

Statistics