The protective effect of red beet powder against carbon tetrachloride induced hepatotoxicity in albino rats

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Red beet consider as functional food and a good source of several bioactive compounds have antioxidant and inflammatory properties that may have health benefits in reducing the risk of  injury diseases. Therefore, in the present work, the effectiveness of red beet in protecting against carbon tetrachloride (CCl4)-induced liver toxicity in rats was studied. The rats were randomly divided into three groups, eight rats per each. First group serves as normal control, second group was treated with CCl4 (1 ml/kg 1:1 mixture with paraffin oil, i.p. twice weekly for 6 weeks) and third group were induced with CCl4 and 10% red beet powder (RBP) adding to diet. Results show that treatment with 10% (RBP) reduced blood biomarkers for liver functions (AST, ALT and ALP) and kidney functions (urea) that were increased by chronic CCl4 intoxication. Also, treatment with RBP significantly increased (P≤ 0.05) in the final body weight, daily food intake which were diminish by CCl4. In addition, RBP inhibited the elevated WBCS, RBCS and PCV values which were high in intoxicated rats. Histological examination support the tested biochemical markers of organs injury. Therefore, the study concluded that RBP as a partial inhibitor and a significant reducer can be a preventive or therapeutic agent due to its antioxidant components.

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