Functional foods extracts app lied in breads ameliorates liver disorders induced by CCl4 in rats

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Liver cancer is one of the most common cancers representing a leading cause of cancer related mortality, with an increasing incidence worldwide. Several strategies to fight cancer and its complications have been proposed, because early discovering, prevention and treatment play a pivotal role in reducing the population burden of cancer. Therefore, the present study was designed to determine the effects of five functional foods of plant source extracts (black caraway seeds, barley wheat, oat wheat, turmeric rhizome and gum Arabic and their mixture bended in bread on liver disorders-induced by CCl4 in rats. Treatment of animals with CCl4 caused a significant increased (p < /em>≤0.05) in serum ALT, AST, ALP and total bilirubin by the ratio of 142.72, 238.21, 37.02 and 568.18% compared to normal controls. Supplementation of the rat diets with pan bread blending with 0.1% w/w of black-caraway seeds  methanol extract (BCSME), barely flour methanol extract (BFME), oat flour methanol extract (EPME), turmeric rhizome methanol extract (TRME), gum arabic  water extract (GAWE) and their mixture significantly (p < /em>≤0.05) decreased these parameters by different ratios. The same behavior was recorded for MDA level in red blood cells, the biomarkers of oxidative stress in tissues.  These results supported our hypothesis that such functional foods extract contains several classes of phytochemicals with other compounds that are able to prevent or inhibit CCl4 hepatotoxicity through liver serum enzymes-lowering activity, decreasing rate on the formation of MDA erythrocytes. Therefore, we recommended like of that functional foods extract by a concentrations ranged 0.1% amount to be included in our daily diets, drinks, food supplements/ additives etc.

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