Potential effects of colostrum against some biochemical changes in alloxan-induced diabetic rats

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Bovine colostrum (BC) has been reported to enhance immune functions and antioxidant defense systems, reduce oxidative stress and fat accumulation, and facilitate the movement of glucose to the muscle. However, very few attempts have been made to examine its anti-diabetic effects in experimental animals. Therefore, the present study aims to evaluate whether BC decreases blood glucose and oxidative stress  as well as enhance the blood lipid profile in diabetic rats induced by alloxan.  Treatment of animals with aloxane caused a significant increased (p < /span>≤0.05) in serum glucose concentration by the ratio 85.59% compared to normal controls. Supplementation of the rat diets with BC by the levels of  5 and10 ml/kg BW decreased this value which recorded 30.80 and 20.40%, respectively.  The same behavior was recorded for some blood lipid profile parameters (triglycerides, total cholesterol, LDL and VLDL) and malonaldialdehyde (MDA, the biomarkers of oxidative stress and inflammation in liver). Also, improving in liver (albumin and globuline) and kidney (urea and creatinine) functions and antioxidant defense systems (SOD and GSH) in diabetic rats have been induced by different rates as the result of supplementation the diet with BC. All of these effects could be attributed to the strong immunological and antioxidant activities of BC as the result of its high bioactive compounds content. These findings provide a basis for the use of BC in prevention and early treatment of T2DM complications which include elevation the levels of blood glucose and oxidative stress, the disturbance in blood lipid profile, liver and kidney functions, and antioxidant defense systems. 

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