Antidiabetic Effect of Marshmallow and Psyllium Leaves in Alloxan Induced Diabetic Rats

The effect of 5% marshmallow (Althaeaofficinalis) and psyllium(Plantago ovate) leaves as powderon biological and biochemical changes of diabetic rats were evaluated. Diabetic rats induced by injection with alloxan (150 mg/kg body weight). A total of 30 rats were divided into 5 groups.6 rats per each as following, first one kept as negative control, second one kept as positive control, third group was fed on 5 % marshmallow leaves, fourth group fed on 10% psyllium leaves, fifth group fed on 10 % marshmallow leaves and six group fed on 10% psyllium leaves. The results showed that group fed on 5% herbal mixture showed the highest values of body weight gain, feed intake and feed efficiency ratio compared with other groups. The highest reduction with significant difference (p≤0.05) in glucose, alkaline phosphatas , and glutamic oxaloacetate transaminase (GOT) levels showed for group as fed on 5% of mixture herbal with values 109.1± 0.40mg/dl, 90± 0.80 µ/l and 17.21± 0.90 µ/l, VS 197± 0.90 and 55.82± 1.35, µ/l respectively.A markedly reduction in glutamic pyruvate transaminase (GPT) levels by different rates in hyperglycemic rats fed on different herbs and its mixtures was observed. Also, group fed on 5% herbal mixture showed the highest decreasing with significant difference(p≤0.05)  in serum triglycerides (TG) and total cholesterol values compared with other tested groups. The maximum reduction of lipid fractions with significant difference also (p≤0.05) in HDL-c, LDL-c and VLDL-c values recorded with group fed on 5% herbal mixture. As conclusion, 5% herbal mixture improvement glucose level, lipid profile, liver and kidney function compared with each herb alone.