Diabetes mellitus is widely distributed all over the world including Egypt, and nearly one of each 10 person is diabetic. Oxidative stress, lipid toxicity and low- grade inflammation as major causes on diabetic complications. Several strategies to improve diabetic complications have been proposed, because early treatment and prevention play a pivotal role in reducing the population burden of diabetes. Therefore, the present study aims to investigate the effectiveness of three methanolic phyto-extracts by-products (pomegranate peel, red onion skin and eggplant peel) blends in meat balls in modulating hyperglycemia using alloxane-induced diabetic rats. Treatment of animals with aloxane caused a significant increased (p < /em>≤0.05) in serum glucose concentration by the ratio 85.59% compared to normal controls. Supplementation of the rat diets with meatballs (20%) decreased this value which recorded 63.64%. The decreasing rate was elevated with the blending of the meatballs with 0.1% w/w by pomegranate peel methanolic extract (PPME), red onion skin methanolic extract (ROSME) and eggplant peel methanolic extract (EPME) and their mixture which recorded 40.87, 30.49, 34.83 and 21.64%, respectively. The same behaviour was recorded for liver tissue MDA level, the biomarkers of oxidative stress and inflammation in liver. Also, improving in liver and kidney functions in diabetic rats have been induced by different rates as the result of supplementation the diet with meatballs blending with the tested phyto by-products extracts. All of these effects could be attributed to the strong antioxidant activity of these extracts as the result of their high phenolics content. These findings provide a basis for the use of the selected phyto by-products extracts for the prevention and early treatment of T2DM.
Elmaadawy, A. (2016). Phyto-extracts applied in beef meatballs ameliorates hyperglycemia and its complications in alloxan-induced diabetic rats. Journal of Home Economics - Menofia University, 26(3), 67-96. doi: 10.21608/mkas.2016.169782
MLA
Ahdab Elmaadawy. "Phyto-extracts applied in beef meatballs ameliorates hyperglycemia and its complications in alloxan-induced diabetic rats". Journal of Home Economics - Menofia University, 26, 3, 2016, 67-96. doi: 10.21608/mkas.2016.169782
HARVARD
Elmaadawy, A. (2016). 'Phyto-extracts applied in beef meatballs ameliorates hyperglycemia and its complications in alloxan-induced diabetic rats', Journal of Home Economics - Menofia University, 26(3), pp. 67-96. doi: 10.21608/mkas.2016.169782
VANCOUVER
Elmaadawy, A. Phyto-extracts applied in beef meatballs ameliorates hyperglycemia and its complications in alloxan-induced diabetic rats. Journal of Home Economics - Menofia University, 2016; 26(3): 67-96. doi: 10.21608/mkas.2016.169782
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