Study on Nephrotoxicity Reduction in Rats Fed on Parsley Plant and Its Products

Document Type : Original research articles

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Abstract

Petroselinumcrispum,is used in traditional medicine for the treatment of diseases. This study was conducedto investigate the protective effect of parsley plant as a parsley leaves decoction, fresh leaves, seeds and seeds oil on Nephrotoxicity reduction in rats by gentamicin (garamycin amp). Thirty six mature albino rats weighting 150±10g were used, and divided into 6 equal groups; one group was kept as a negative control group, while the other groups were injected by gentamicin once day for 10 days. The used plants (parsley and its products) given as a percent of 20% decoction, 10% fresh leaves, 5%seeds and 5% seeds oil from the basal diet. Liver functions (GOT, GPT, total protein, albumin),kidney functions (urea, creatinin, uric acid), total cholesterol, triglycerides, lipoproteins (HDL, LDL, VLDL) andhistopathological changes of kidney, liver and spleen,wereexamined. The obtained results concluded that the feeding with the tested plant (parsley and its products) improved kidney functions, liver functions and lipid profile.

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