The Effect of Gum Arabic (Liquid/Solid State)Feeding on Acute Kidney Injuries in Rats

Many studies checked theGum Arabic (GA) effects on retarded kidney functions, but there is a dearth of information regarding what the shape that could be more efficient for human? Therefore, the present study conducted to investigate and compare the effect ofGA intakes as liquid or powder shape feeding on rats suffered from acute kidney injury (AKI) or nephrotoxicty induced by gentamicin (GM). Thirty two adult male albino rats weighing about 150 ± 10g were divided into two main groups; the first, negative control (C-), was eight normal rats fed on basal diet, while the second (n =24 rats) were injected intraperitoneal (i.p.) with GM in a dose of 80 mg/kg b. wt./day for 8 consecutive days to induce AKI. After lesion confirmation, rats were divided into three sub-groups (8 rats /each) and fed on basal diet only (positive control C+group), or with GA colloidal solution (10%) administered orally (20 ml/kg body weight), or with 2% GA supplementation of total diet weight as powder for 28 consecutive days. Results showed that GM injection elevated significantly (p<0.05) the levels of uric acid, urea, createnine, AST&ALT activity,TC andLDL-c in serum, also MDA and NO levels in kidney tissues. While decreased significantly (p<0.05) the potassium, sodium, total proteins, albumin, globulin in serum and SOD levels in kidney tissues compared with C- group. Nutritional intervention with GA ameliorated significantly all theseparameters and restored the normal structure of kidney cells,whereas no significant differences between the two shapes used were reported for the effectiveness on all parameters assessed. In conclusion, nutritional supplementation with GA as a liquid (10%) or powder (2%) ameliorated significantly the accompanied symptoms of AKI, without any significant difference for the effectiveness of the shape used