Anti-diabetic Effect of Black Mulberry Leaves(Morus nigra, L.) in Streptozotocin-Induced Diabetic Rats

The effect of different levels of black mulberry leaves (Morus nigra, L.) 2.5, 5% as powder and 250 & 500 mg/kg as extract on diabetic rats were evaluated using 36 rats which divided for 6 groups. Also, phenolics compounds were determined. Results showed that the values of total phenols, total flavonoid and anthocyanin contents of mulberry leaves were 13.80±0.93, 61.40±0.35 and 3.70±0.61 mg/g, respectively. The highest phenolic compounds of mulberry leaves recorded for pyrogallol and syringic acid. The mean values were 223.3 and 80.12 mg/100g, respectively. While, the lowest values recorded for gallic acid and vanillic acid. The mean values were 9.97 and 7.15 mg/100g, respectively. Group rats administrated with 500 mg/kg extract of black mulberry leaves showed highest valueswith significant differences of BWG, FI and FERcompared with other groups.The highest reduction with significant difference in GOT, GPT andALPlevels recorded with group administrated with 500 mg/kg black mulberry leaves extract compared with other  groups.The maximum reduction with significant difference in serum triglycerides and total cholesterol recorded with group administrated on 500 mg/kg black mulberry leaves extract.The highest reduction with significant difference in VLDL-c value recorded for group administrated with 5% black mulberry powder, while, the maximum increment with significant difference in HDL-c value recorded with group administrated with 500 mg/kg black mulberry leaves extract. The maximum reduction with significant difference in LDL-c value recorded with group fed on 500 mg/kg black mulberry leaves extract. The highest reduction with significant difference in serum urea, uric acid and creatinine value recorded with group administrated with 500 mg/kg black mulberry leaves extract.