Anti Hyperglycemic Effects Of Citrullus Vulgaris (Colocynth) And Rosmarinus Officinalis ( Rosmary ) In Streptozotocin-Induced Diabetic Rats

Citrullus vulgaris (Colocynth) and Rosmarinus officinalis             (Rosmary)has great potential as an antioxidant and an anti hyperglycemic agent in vitro.The plants are rich in many pharmaceutical active ingredients like tannins,flavonal and lignans.Thus the present study was designed to investigate anti hyperglycemic effects of Citrullus vulgaris (Colocynth) and Rosmarinus officinalis ( Rosmary ) powder in streptozotocin-induced diabetic rats. Twenty five Sprague-Dawley rats were randomized into 5 equal groups. Group1 negative control group and the other groups were injected with twice intraperitoneal (i.p) injection with Streptpzotocin (STZ) (30 mg/kg body weight).The difference between first and second injection was three days to induce diabetes.Group 2 positive control, group and groups 3,4 and 5 were given (Colocynth) , ( Rosmary ) and mixture of them at concentiration of 5% after the second injection with STZ for 4 weeks. Blood samples were collected for serum biochemical analyses, also the Liver and kidney were taken for histopathological examination. The   (Colocynth) , ( Rosmary ) powder and mixture of them significantly reduced body weight gain, feed intake and feed efficiency ratio, normalized serum levels of liver enzymes and kidney function parameters, improved lipid profile, decreased blood glucose in diabetic rats.Histopathological examination showed amelioration of histopathological lesions seen in the liver and kidneys of experimental diabetic rats.Plants exhibited hepatoprotective, hypolipidemic and antidiabetic effects in diabetic rats.The study recommends that the (Colocynth) , ( Rosmary ) powder should be further investigated as a new supplement for the management of diabetes